At META-IMAGEOMICS research laboratory, we investigate human metabolism by integrating advanced medical imaging with deep molecular and physiological phenotyping using multiomics. Our research focuses on understanding how different tissues, particularly brown and white adipose tissue, regulate energy balance, insulin sensitivity, and susceptibility to metabolic disease.<\/p>\n\n\n\n
We combine state-of-the-art imaging technologies with comprehensive multi-omics and metabolic assessments to capture a 360\u00b0 view of human physiology. By uniting imaging with mechanistic and translational approaches, we aim to uncover actionable biomarkers and pathways that can guide new strategies for preventing and treating obesity, type 2 diabetes, and related cardiometabolic disorders.<\/p>\n\n\n\n
To examine metabolism at multiple levels \u2014 whole-body, tissue, cellular, and molecular \u2014 we utilise a powerful toolkit that includes: We aim to transform medical imaging from a diagnostic tool into a mechanistic engine<\/strong> for understanding human physiology. By combining total-body imaging with omics technologies, dynamic metabolic measurements, and targeted interventions, our research seeks to: Our ultimate goal is to advance translational metabolism<\/strong> \u2014 turning mechanistic discoveries into meaningful clinical insights for the prevention and treatment of metabolic disease.<\/p>\n\n\n\n At META-IMAGEOMICS research laboratory, we investigate human metabolism by integrating advanced medical imaging with deep molecular and physiological phenotyping using<\/p>\n
\u2022 PET imaging<\/strong> to quantify tissue-specific metabolism, substrate use, and receptor function
\u2022 CT scanning<\/strong> for anatomical assessments and tissue composition
\u2022 MRI <\/strong>for structural, functional, and metabolic imaging
\u2022 Metabolomics, proteomics, transcriptomics<\/strong> and lipidomics<\/strong> for systemic biochemical profiling
\u2022 Continuous glucose monitoring<\/strong> to capture real-time glycaemic dynamics
\u2022 Blood samples<\/strong> for hormones, metabolites, cytokines, and molecular markers
\u2022 Gut microbiome profiling<\/strong> to explore host\u2013microbe metabolic interactions
\u2022 Hormone measurements<\/strong> to assess endocrine regulation of energy balance
\u2022 Indirect calorimetry<\/strong> for whole-body energy expenditure and substrate oxidation
\u2022 Hyperinsulinaemic\u2013euglycaemic clamps<\/strong> to quantify insulin sensitivity and metabolic flexibility
\u2022 Pharmacological and Nutraceutical<\/strong> interventions<\/strong> to test metabolic pathways in vivo<\/em>
\u2022 Behavioural interventions<\/strong> (diet, cold exposure) to study adaptable metabolic responses<\/p>\n\n\n\nResearch Vision<\/strong><\/h4>\n\n\n\n
\u2022 decode tissue-specific metabolic processes in vivo,
\u2022 map inter-organ metabolic networks,
\u2022 identify early markers of metabolic dysfunction,
\u2022 and discover targets that improve metabolic health.<\/p>\n\n\n\n
<\/p>\n","protected":false},"excerpt":{"rendered":"